Lung Cancer

Lung cancer originates from tissues of the lung, usually from cells lining the air passages. The two main types are small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). This is diagnosed based on how the cells look under a microscope.

Non-small cell lung cancer (NSCLC)

NSCLC is the more common type of lung cancer, comprising of approximately 80% of lung cancers. It is less aggressive than SCLC. If discovered early, surgery and/or radiation therapy, chemotherapy may offer a chance of cure.

Small cell lung cancer (SCLC)

SCLC is fast-growing and rapidly spreads through the bloodstream and lymphatics to other parts of the body. It is often advanced at diagnosis. It is usually treated with chemotherapy alone or in combination with radiotherapy.

Doctors cannot always explain why one person develops lung cancer and another does not. However, we do know that a person with certain risk factors may be more likely than others to develop lung cancer.

Smoking is the major risk factor for lung cancer. It is responsible for more than 80% of all lung cancer worldwide. Harmful substances in smoke damage lung cells. Over time, the damaged cells may become cancerous. This is why smoking cigarettes, pipes, or cigars can cause lung cancer. Inhaling secondhand smoke can also cause lung cancer in non-smokers. The more a person is exposed to smoke, the greater the risk of lung cancer. Similarly, the earlier in life a person smokes and the more years he smokes, the greater the risk of lung cancer.

Other risk factors for lung cancer include being exposed to radiation such as radon (a radioactive gas), asbestos, arsenic, chromium, nickel, soot and tar in workplaces, living in places with air pollution and getting older. People with family members who had lung cancer may be at slightly increased risk of the disease. People who have had lung cancer are at increased risk of developing a second lung tumour.

Early lung cancer often does not cause symptoms. But as the cancer grows, common symptoms may include:

• A cough that gets worse or does not go away
• Breathing trouble, such as shortness of breath
• Constant chest pain
• Coughing up blood
• A hoarse voice
• Frequent lung infections, such as pneumonia
• Feeling very tired all the time
• Weight loss with no known cause

Usually these symptoms are not due to cancer as other health problems can cause some of these symptoms. However, anyone with such symptoms which persists should see a doctor to be diagnosed and treated as early as possible.

If you have symptoms that suggests lung cancer, your doctor must find out whether it is truly likely cancer or other health conditions. You may be required to do some blood tests and X-rays or scans.

Physical Examination

• Chest X-ray
• Computed Tomography (CT) Scan

Your doctor may then order one or more of the following tests to collect samples to confirm the diagnosis if there is a high suspicion of lung cancer:

• Sputum cytology: Thick fluid (sputum) is coughed up from the lungs. The lab checks samples of sputum for cancer cells.
• Bronchoscopy: The doctor uses a long needle to remove fluid (pleural fluid) from the chest. The lab checks the fluid for cancer cells.
• Bronchoscopy: The doctor inserts a thin, lighted tube (a bronchoscope) through the nose or mouth into the lung. The doctor may take a sample of cells with a needle, brush, or other tool. The doctor also may wash the area with water to collect cells in the water.
• Fine-needle aspiration: The doctor uses a thin needle to remove tissue or fluid from the lung or lymph node.
• Open biopsy: In cases where the tumour tissue is difficult to obtain, direct biopsy of the lung tumour or lymph nodes through an incision in the chest wall may be needed.

After lung cancer has been diagnosed, tests are done to determine if the cancer cells have spread from the lungs to other parts of the body.

To plan the best treatment, apart form the type of lung cancer, your doctor needs to know the extent (stage) of the disease. Staging, usually done with CT scans, PET-CT scans or MRI, is to find out whether the cancer has spread, and if so, to what parts of the body. Lung cancer spreads most often to the lymph nodes, brain, bones, liver, and adrenal glands.

What treatment is offered?

Depending on the stage of the lung cancer, the aims of treatment may be for cure, control of disease for prolongation of survival or management of symptoms and prevention of complications to improve quality of life. The following treatment modalities may be used singly or in combination.

Localised Non-Small Cell Lung Cancer

For localised lung cancers, treatment consists of surgery with or without chemotherapy, radiation alone or combined chemotherapy and radiation.

Surgery

Surgery for lung cancer involves the removal of tissues that contain the tumour and nearby lymph nodes.

Radiation Therapy

Radiation therapy (also called radiotherapy) uses high energy rays to kill cancer cells. It affects cells only in the treated area.

Chemotherapy

Chemotherapy uses anticancer drugs to shrink/kill cancer cells. This is usually given as an infusion. The drugs enter the bloodstream and can affect cancer cells all over the body.

Advanced Non-small cell lung cancer

When non-small cell lung cancer has spread to distant organs, the aim of the treatment is to control the cancer, improve symptoms and quality of life and prolong survival. The possible treatment modalities include chemotherapy and immunotherapy.

Targeted Therapy

Targeted therapy uses drugs to block the growth and spread of cancer cells. For example, some lung cancer cells have too much EGFR which is a protein on the surface of cells which helps the cells grow and divide faster. Drugs called EGFR inhibitors can block the signal from EGFR and stop the lung cancer cells from growing. The drugs enter the bloodstream and can affect cancer cells all over the body. Some patients with non-small cell lung cancers with EGFR mutation positive that has spread will receive targeted therapy.

Immunotherapy

Immunotherapy refers to a type of cancer treatment designed to enhance one’s body’s immune system to fight cancer cells. Cancer cells have the ability to ‘camouflage’ themselves in such a way that our body’s immune system is unable to detect these ‘rogue cells’ to destroy them. Immunotherapy helps by boosting the immune system so that it can detect and destroy these “rouge” cancerous cells more easily. As a result, in certain cancers, it had been shown to be able to control and keep things at bay for a longer period of time, compared to other treatments.

Screening

Screening refers to looking for cancer before a person has any symptoms. The aim is to detect cancers early so that it can be treated at an early stage. Screening tests are tests that may help doctors find and treat cancer early. Several methods of detecting lung cancer have been studied as possible screening tests such as low dose CT lung scans. However, this is only found to be effective in high risk people.

Hence it is important to talk with your doctor about your own risk factors and the possible benefits and harms of being screened for lung cancer. Like many other medical decisions, the decision to be screened is a personal one. Your decision may be easier after learning the pros and cons of screening.